Citicoline mechanism of action








Citicoline (CDP-choline) mechanisms of action and effects in

11/19/2014
09:10 | Author: Jeremy Rodriguez

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Citicoline (CDP-choline) mechanisms of action and effects in

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. D'Orlando KJ, Sandage BW Jr. Citicoline is approved in Europe and Japan.

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Membrane repair and regeneration is necessary for recovery from stroke. It is presently being evaluated in phase II/III stroke trials in the United States. Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis. Citicoline is approved in Europe and Japan for use in stroke, head trauma and other neurological disorders. Data from many pre-clinical and clinical trials support the hypothesis that citicoline may be a safe and effective treatment for stroke. Furthermore, citicoline may alleviate free fatty acid-induced toxicity which accompanies ischemic insult.

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Citicoline neuroprotective mechanisms in cerebral ischemia

9/18/2014
07:40 | Author: Jeremy Rodriguez

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Citicoline neuroprotective mechanisms in cerebral ischemia

Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. The therapeutic action of.

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Citicoline also provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release. Citicoline neuroprotection may include: (i) preserving cardiolipin (an exclusive inner mitochondrial membrane component) and sphingomyelin; (ii) preserving the arachidonic acid content of PtdCho and phosphatidylethanolamine; (iii) partially restoring PtdCho levels; (iv) stimulating glutathione synthesis and glutathione reductase activity; (v) attenuating lipid peroxidation; and (vi) restoring Na(+)/K(+)-ATPase activity. Based on these findings, a singular unifying mechanism has been hypothesized. Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. This review attempts to shed some light on the properties of citicoline that are responsible for its effectiveness. The therapeutic action of citicoline is thought to be caused by stimulation of PtdCho synthesis in the injured brain, although the experimental evidence for this is limited. Our studies in transient cerebral ischemia suggest that citicoline might enhance reconstruction (synthesis) of PtdCho and sphingomyelin, but could act by inhibiting the destructive processes (activation of phospholipases). These observed effects of citicoline could be explained by the attenuation of phospholipase A(2) activation. Cytidine-5'-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain.

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Citicoline Indication and Nursing Management Nursing Crib

7/17/2014
05:10 | Author: Jeremy Rodriguez

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Citicoline Indication and Nursing Management Nursing Crib

Classification: Neurotonics, Nootropics. Mechanism of Action. Citicoline seems to increase a brain chemical called phosphatidylcholine.

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Citicoline neuroprotective mechanisms in cerebral ischemia

5/16/2014
03:00 | Author: Jeremy Rodriguez

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Citicoline neuroprotective mechanisms in cerebral ischemia

Table 1 Recent studies (since 1995) investigating the action of citicoline in neuropathological conditions. Study Citicoline: protective mechanisms in stroke. 1.

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What Is Citicoline And What Is It Used For? - Nootriment

3/15/2014
01:10 | Author: Jeremy Rodriguez

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What Is Citicoline And What Is It Used For? - Nootriment

So what exactly is Citicoline and how does it work? This article will introduce the benefits, mechanism of action and side effects of Citicoline.

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The two main components of the supplement, cytidine and choline, are broken down and then widely distributed. As it becomes incorporated into phospholipids it helps to activate their continued biosynthesis. After taking a Citicoline dosage, this compound is absorbed into the bloodstream fairly quickly and then crosses the blood-brain barrier, reaching the brain.

Dopamine and Norepinephrine levels are also increased throughout the central nervous system.

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