Common antiepileptic side effects








Side effects of antiepileptics--a review

10/20/2014
09:37 | Author: Molly Young

Common antiepileptic side effects
Side effects of antiepileptics--a review

Older generation antiepileptic drugs like Phenobarbital (Luminal), carbamazepine In addition to the common side effects of antiepileptic drugs, like dizziness.

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Older generation antiepileptic drugs like Phenobarbital (Luminal), carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote) have several shortcomings such as suboptimal response rates, significant adverse effects, several drug interactions, and a narrow therapeutic index. These newer generation antiepileptics like felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), tiagabine (Gabitril), topiramate (Topamax), and zonisamide (Zonegran) have better tolerability profiles, low interaction potential, and significantly less enzyme inducing or inhibiting properties. In addition to the common side effects of antiepileptic drugs, like dizziness, drowsiness, and mental slowing; other side effects like weight gain, metabolic acidosis, nephrolithiasis, angle closure glaucoma, skin rash, hepatotoxicity, colitis, and movement and behavioral disorders, to name a few, have been brought to our attention. New antiepileptic drugs have been developed in the last decade to overcome some of these problems. As the use of antiepileptic drugs has expanded to include treatment of neuropathic pain, newer side effects have been reported. This review is an attempt to highlight the features and incidences of some of these side effects.

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Behavioral Side Effects of Antiepileptic Drugs

12/19/2014
07:14 | Author: Chloe Allen

Common antiepileptic side effects
Behavioral Side Effects of Antiepileptic Drugs

Although behavioral side effects (BSEs) are fairly common with antiepileptic drugs (AEDs), information in the pharmacy literature is sparse.

Pond, PhD Associate Professor of Pharmaceutical Sciences Bill Gatton College of Pharmacy East Tennessee State University Johnson City, Tennessee US Pharm. Miller, PharmD, BCPS, BCPP Assistant Professor of Pharmacy Practice Brooks B. Jim Thigpen, PharmD, BCPS Assistant Professor of Pharmacy Practice Stacy E. 2013;38(11):HS15-HS20.

This mechanism is relevant for phenobarbital, clobazam, clonazepam, tiagabine, vigabatrin, primidone (via its metabolite, phenobarbital), valproic acid, felbamate, lamotrigine, topiramate, and zonisamide.3,7 GABA-ergic synapse dysfunction has been shown to contribute to aggressive behavior and schizophrenia.11,12.

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Department of Neurology - Medical Treatment - Antiepileptic Drug

10/18/2014
05:29 | Author: Nicholas Clark

Common antiepileptic side effects
Department of Neurology - Medical Treatment - Antiepileptic Drug

Common and/or important side effects (SE) will be listed. Remember, all antiepileptic drugs (AEDs) can cause side effects. Some do not depend on how long.

If you read the package insert of any drug (or read the Physician's Desk Reference / PDR) you might think all medicines are poison. This Table is meant to simplify this task. Not so, but the list of all reported side effects is long and confusing.

Some side effects can only be determined with lab work (e.g. Blood levels are not a good measure of "too much". hyponatremia - low salt levels in the blood, from carbamazepine and oxcarbazepine). People react differently. decreased sex drive). Common and/or important side effects (SE) will be listed. Remember, all antiepileptic drugs (AEDs) can cause side effects. All AEDs (even gabapentin) can cause a rash. Some do not depend on how long and how much you are taking, some do. Some can not be determined by lab (e.g.

Lastly, there is the economic aspect. Many AEDs are very expensive, and this can also have an adverse effect on the patient.

Pregnancy should be planned. Women have special issues regarding AEDs because of pregnancy, birth control pills, and breast feeding.

The FDA Medical Products Reporting Program (free) Clinical Pharmacology 2000 (free registration) Physician's Desk Reference (free registration). Finally, it would be remiss of me not to give some links.

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Neurology Antiepileptic medications - The Royal Children39s Hospital

8/17/2014
03:08 | Author: Chloe Allen

Common antiepileptic side effects
Neurology Antiepileptic medications - The Royal Children39s Hospital

All medications have the possibility of causing side effects. Some mild side effects are common when starting antiepileptic.

Effects when taken with alcohol If alcohol is taken in combination with antiepileptic medication, extra sedative effects can occur. Also, alcohol increases the likelihood of seizures.

Not all antiepileptic medications need to be monitored with drug levels, as there is not a good correlation between drug level and effect. These blood levels are generally measured before a dose is due. phenytoin, phenobarbitone, carbamazepine). For some medications, children need to have blood tests to determine the level in the bloodstream (eg.

Many drugs interact with each other, so it is very important to always seek the advice of a doctor or pharmacist before taking any other medications with antiepileptic medications.

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Adverse Effects of Antiepileptic Drugs - Wiley Online Library

6/16/2014
01:25 | Author: Molly Young

Epileptic drugs
Adverse Effects of Antiepileptic Drugs - Wiley Online Library

And data collection in different studies. The FDA also has suggested the use of other statistical methods to allow comparison of adverse effects from different.

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