Dog epilepsy phenobarbital side-effects








Phenobarbital Side Effects in Dogs

01/31/2015
06:20 | Author: Jeremy Rodriguez

Dog epilepsy phenobarbital side-effects
Phenobarbital Side Effects in Dogs

Phenobarbital side effects are a valid concern when using this drug to treat epilepsy and seizures in dogs. Other drugs with fewer side effects are now available.

2012 VetInfo.

Despite side effects, phenobarbital is currently one of the most commonly used, least expensive and most effective options for successful treatment. Other drugs with fewer side effects are now available, but come with a hefty price tag. Phenobarbital side effects are a valid concern when using this drug to treat epilepsy and seizures in dogs.

Phenobarbital side effects can occur both over the short-term and long-term. The most common long-term side effect associated with the use of phenobarbital is liver damage.

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01 Phenobarbital - - a VIN company!

01/31/2015
04:00 | Author: Jeremy Rodriguez

Dog epilepsy phenobarbital side-effects
01 Phenobarbital - - a VIN company!

Uses of this Medication. When animals have frequent seizures, medication becomes necessary. In dogs and cats, the barbiturate phenobarbital.

Date Published : 1/1/2001 Date Reviewed/Revised: 06/12/2013.

The use of phenobarbital will interfere with thyroid function testing as well as with adrenal function testing. It is important not to discontinue phenobarbital "cold turkey" as doing so may precipitate severe seizures. Liver toxicity is associated with blood levels of 35 ug/ml or higher. With time, the patients liver becomes especially able to remove phenobarbital from the system and the level may go down. If high blood levels of phenobarbital are required to control seizures, a second medication (usually potassium bromide ) should be added so as to reduce the phenobarbital dose required.

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Has anybody had their dog put on phenobarbital for seizures on an

01/31/2015
02:00 | Author: Jeremy Rodriguez

Dog epilepsy phenobarbital side-effects
Has anybody had their dog put on phenobarbital for seizures on an

Has anybody treated their epileptic dog with phenobarbital only when make my dog hyperactive and clumsy, which are also the symptoms he.

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Therapeutic efficacy of phenobarbital and primidone in canine

01/31/2015
12:20 | Author: Jeremy Rodriguez

Dog epilepsy phenobarbital side-effects
Therapeutic efficacy of phenobarbital and primidone in canine

The efficacy of phenobarbital and primidone against canine epilepsy was compared in a Phenobarbital/adverse effects; Phenobarbital/therapeutic use*.

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Phenobarbital is, therefore, regarded as the drug of first choice for the treatment of canine epilepsy. A further six dogs on phenobarbital, and seven dogs on primidone, were classified as 'improved', i.e. Both drugs were dosed according to the clinical requirement; the daily doses ranged from 5-17 mg/kg phenobarbital and from 17-70 mg/kg primidone. Complete control of tonic-clonic seizures for 6 months, at least, was attained in six out of fifteen dogs of the phenobarbital group, and in five out of twenty dogs in the primidone group. The efficacy of phenobarbital and primidone against canine epilepsy was compared in a controlled study. Thirty-five dogs showing generalized tonic-clonic seizures (grand mal), treated for a minimum of 6 months, were included in the study; fifteen of these were treated with phenobarbital, the other twenty with primidone. The plasma concentrations of phenobarbital, or of primidone and its metabolites phenobarbital and phenylethylmalondiamide (PEMA), were routinely monitored. The difference between the efficacy of phenobarbital and primidone was not significant, but primidone gave rise to signs of liver toxicity in fourteen out of twenty dogs, as indicated by considerable elevations of liver enzyme values (alanine transferase, glutamate dehydrogenase, alkaline phosphatase). the rate of seizures was reduced by at least 50%. The rest of the dogs were not improved by the treatment.

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