Data sources include Micromedex (updated Sep 26th, 2014), Cerner Multum (updated Oct 16th, 2014), Wolters Kluwer (updated Oct 9th, 2014) and others. To view content sources and attributions, refer to our editorial policy.
Your blood may need to be tested often. Visit your doctor regularly. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Allopurinol can lower blood cells that help your body fight infections.
Case Report: 100 mg orally daily.
You should not take allopurinol if you are allergic to it.
Uric acid buildup can lead to gout or kidney stones. Allopurinol reduces the production of uric acid in your body.
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urinating less than usual or not at all;
Allopurinol may also be used for purposes not listed in this medication guide.
It is not known whether allopurinol will harm an unborn baby. l your doctor if you are pregnant or plan to become pregnant while using this medication. FDA pregnancy category C. Allopurinol can pass into breast milk and may harm a nursing baby. Do not use this medication without ling your doctor if you are breast-feeding a baby.
a diuretic (water pill).
Visit your doctor regularly. Allopurinol can lower blood cells that help your body fight infections. Your blood may need to be tested often. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.
Allopurinol may impair your thinking or reactions. It can make your condition worse. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol.
Daily exercise may significantly reduce the risk of heart failure, according to new research. Heart failure, a common, disabling condition in older adults.
Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Take the missed dose as soon as you remember.
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
Researchers followed more. Gout, a form of inflammatory arthritis, appears to increase the risk of type 2 diabetes, especially in women, a new study finds.
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if you are receiving any chemotherapy.
To make sure you can safely take allopurinol, l your doctor if you have any of these other conditions: kidney disease; liver disease; diabetes; congestive heart failure;
Maintenance: 200 to 300 mg/day orally until patient no longer at high risk for developing hyperuricemia. Initial: Parenteral: 200 to 400 mg/m2/day to a maximum of 600 mg/day Oral: 600 to 800 mg/day for 1 to 3 days with consumption of at least 2 L of fluid/day.
high blood pressure; or.
Usual Allopurinol Adult Dose for Cardiothoracic Surgery:
Study (n=11) to prevent the formation of superoxide free radicals and improve endothelial function (in NYHA class II to III chronic heart failure): 300 mg orally daily for 1 month.
Maintenance: 200 to 300 mg (mild gout) orally once a day or 400 to 600 mg/day (moderay severe tophaceous gout) in divided doses. Initial: 100 mg orally once a day.
Usual Allopurinol Adult Dose for Hyperuricemia Secondary to Chemotherapy:
l your doctor about all other medicines you use, especially: azathioprine (Imuran); chlorpropamide (Diabinese);
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
Usual Allopurinol Adult Dose for Reactive Perforating Collangenosis:
Generic Name: allopurinol (al oh PURE i nole) Brand Names: Zyloprim, Lopurin, Aloprim.
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.
Revision Date: 10/12/2010 10:11:13 AM. Version: 5.01. Cerner Multum, Inc.
Availability Rx Prescription only.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Drug information contained herein may be time sensitive. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Usual Allopurinol Adult Dose for Gout:
a blood thinner such as dicoumarol or warfarin (Coumadin); or.
Pregnancy Category C Risk cannot be ruled out.
Less serious allopurinol side effects may include: vomiting, diarrhea; drowsiness, headache;
Gout Uloric Zyloprim febuxostat probenecid Benemid Krystexxa Aloprim devil's claw More.
Calcium Oxalate Calculi with Hyperuricosuria Zyloprim Aloprim More.
To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor ls you otherwise. You may have gout attacks more often when you first start taking allopurinol. Your doctor may recommend other gout medication to take with allopurinol. Take each dose with a full glass of water. Keep using your medication as directed and l your doctor if your symptoms do not improve after a few months of treatment.
Greater than 10 years: 600 to 800 mg/day in 2 to 3 equally divided doses. Oral: Less than 6 years: 150 mg/day orally in 3 divided doses. Parenteral : Less than or equal to 10 years: 200 mg/m2/day in 1 to 3 equally divided doses not to exceed 600 mg/24 hours. Greater than 10 years: 200 to 400 mg/m2/day administered in 1 to 3 equally divided doses, not to exceed 600 mg/24 hours. 6 to 10 years: 300 mg/day orally in 2 to 3 divided doses. All doses greater than 300 mg should be given in equally divided doses.
Usual Allopurinol Pediatric Dose for Leishmaniasis:
Case Reports -- Mania (bipolar I) associated with hyperuricemia: 300 mg orally daily.
See also: Pregnancy and breastfeeding warnings (in more detail).
Usual Allopurinol Adult Dose for High Risk Percutaneous Transluminal Angioplasty:
Case Reports - Visceral leishmaniasis, post renal transplant: 300 mg daily plus meglumine antimoniate (50 mg/kg/day). Study (n=31 - Cutaneous leishmaniasis: 20 mg/kg/day plus low-dose meglumine antimoniate (30 mg/kg/day) for 20 days.
Seek emergency medical attention or call the Poison Help line at.
See also: Side effects (in more detail).
Store allopurinol at room temperature away from moisture and heat.
Studies: Coronary Artery Bypass Graft Surgery 600 mg orally one day prior to surgery and another 600 mg orally the day of surgery.
Take allopurinol exactly as prescribed by your doctor. Follow the directions on your prescription label. Do not take in larger or smaller amounts or for longer than recommended.
Usual Adult Dose for Leishmaniasis:
nausea, upper stomach pain, itching, loss of appetite, weight loss, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
Avoid being near people who are sick or have infections. l your doctor at once if you develop signs of infection.
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Hyperuricemia Secondary to Chemotherapy sodium bicarbonate Zyloprim rasburicase Elitek Aloprim Neut More.
Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor ls you otherwise. Do not use allopurinol if you have ever had a serious allergic reaction to allopurinol. Stop taking the medicine and call your doctor at once if you have any signs of skin rash, no matter how mild.
You may report side effects to FDA at 1-800-FDA-1088. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
cyclosporine (Gengraf, Sandimmune, Neoral); mercaptopurine (Purinethol);
CSA Schedule N Not a controlled drug.
severe tingling, numbness, pain, muscle weakness; or.
Be careful if you drive or do anything that requires you to be alert. It may worsen your condition. Avoid drinking alcohol. Allopurinol may impair your thinking or reactions.
Usual Adult Dose for Congestive Heart Failure:
This list is not complete and other drugs may interact with allopurinol. Do not start a new medication without ling your doctor. l your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products.
joint pain, flu symptoms;
Maintenance: 300 mg/day or less. Initial: 200 to 300 mg orally once a day.
Your doctor may occasionally change your dose to make sure you get the best results.
Approval History Calendar Drug history at FDA.
pain or bleeding when you urinate;
an antibiotic such as ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox);
Usual Pediatric Dose for Hyperuricemia Secondary to Chemotherapy:
Follow your diet and medication routines very closely. Your doctor may recommend a special diet to help treat your condition.
Study (n=38) - Primary Percutaneous Transluminal Coronary Angioplasty (PTCA): 400 mg orally administered immediay after admission to the emergency department (approximay 60 minutes before reperfusion) and after primary PTCA was completed.
Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.
changes in your sense of taste; or muscle pain.
Usual Allopurinol Adult Dose for Calcium Oxalate Calculi with Hyperuricosuria:
Get emergency medical help if you have any of these signs of an allergic reaction to allopurinol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using allopurinol and call your doctor at once if you have a serious side effect such as:.
Greater than 5 years old Study (n=31) - Cutaneous leishmaniasis: 20 mg/kg/day plus low-dose meglumine antimoniate (30 mg/kg/day) for 20 days.
Heart bypass patients might not need to follow strict blood sugar control after their surgery, according to a new study. Some previous research suggested that.
the first sign of any skin rash, no matter how mild;
Usual Allopurinol Adult Dose for Mania:
Gout medicine side effects