Mechanism of action of mefenamic acid








DrugBank Mefenamic acid (DB00784)

11/20/2014
02:21 | Author: Nicholas Clark

Cheap clonazepam for sale
DrugBank Mefenamic acid (DB00784)

Mechanism of action, Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin.

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Mefenamic acid is also glucuronidated directly. The activity of these metabolites has not been studied. Mefenamic acid undergoes metabolism by CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur. Kind: protein Organism: Human Pharmacological action: yes Actions: inhibitor Kind: protein Organism: Human Pharmacological action: unknown Actions: inhibitor Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate inhibitor Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate inhibitor.

Comments (0)



Mefenamic acid - Wikipedia, the free encyclopedia

11/19/2014
12:18 | Author: Jeremy Rodriguez

Cheap clonazepam for sale
Mefenamic acid - Wikipedia, the free encyclopedia

[edit]. Mefenamic acid is a competitive inhibitor of COX-1 and COX-2, which are responsible for the first committed step in.

noco ( m / d / e / h / v / s )/ cong / tumr, sysi / epon, injr.

Known mild side effects of mefenamic acid include headaches, nervousness and vomiting. It is advised to consult a doctor immediay if these symptoms appear while taking this medication. Serious side effects may include diarrhea, hematemesis (vomiting blood), haematuria (blood in urine), blurred vision, skin rash, itching and swelling, sore throat and fever.

Decreasing the activity of these enzymes thus reduces the production of prostaglandins, which are implicated in inflammation and pain processes.

Comments (2)Read more

Mefenamic Acid - FDA prescribing information, side effects and uses

9/18/2014
02:23 | Author: Steven Lewis

Cheap clonazepam for sale
Mefenamic Acid - FDA prescribing information, side effects and uses

The mechanism of action of Mefenamic Acid, like that of other NSAIDs, is not compley understood but may be related to prostaglandin synthetase inhibition.

Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Long-term administration of NSAIDs have resulted in renal papillary necrosis and other renal injury. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.

Comments (3)Read more

Pons (Mefenamic Acid) Drug Information Clinical Pharmacology

7/17/2014
04:56 | Author: Chloe Allen

Clonazepam for sale online
Pons (Mefenamic Acid) Drug Information Clinical Pharmacology

The mechanism of action of Pons (mefenamic acid) , like that of other NSAIDs, is not compley understood but may be related to prostaglandin synthetase.

Pons (mefenamic acid) was significantly superior to placebo in all parameters, and both treatments (drug and placebo) were equally tolerated. The parameters used in determining efficacy included pain assessment by both patient and investigator; the need for concurrent analgesic medication; and evaluation of change in frequency and severity of symptoms characteristic of spasmodic dysmenorrhea. In controlled, double-blind, clinical trials, Pons (mefenamic acid) was evaluated for the treatment of primary spasmodic dysmenorrhea.

Comments (4)Read more

Effects of mefenamic acid on menstrual hemostasis in essential

5/16/2014
06:55 | Author: Molly Young

Cheap clonazepam for sale
Effects of mefenamic acid on menstrual hemostasis in essential

To obtain insight into their mechanism of action, we measured menstrual blood loss in menorrhagic women, who were receiving mefenamic acid (500 mg, three.

more. Warning: The NCBI web site requires JavaScript to function.

The subjects' uteri were extirpated in the first 24 hours of menstruation, and light and electron microscopy were used to perform morphologic and morphometric studies. In addition we studied the morphology of early menstrual hemostasis. In the group treated with mefenamic acid mean menstrual blood loss was decreased by 40%. These data suggest that mefenamic acid may act through an improvement of plaet aggregation and degranulation and through increased vasoconstriction. To obtain insight into their mechanism of action, we measured menstrual blood loss in menorrhagic women, who were receiving mefenamic acid (500 mg, three times daily) (n = 6) or placebo (n = 5) in a double-blind way. In uteri of the women treated with mefenamic acid hemostatic plugs were further transformed, and fewer vessels without a plug were observed than in uteri of the group receiving placebo. Prostaglandin synthesis inhibitors decrease menstrual blood loss by 30% to 50% in patients with essential menorrhagia.

National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA. National Center for Biotechnology Information, U.S.

Generate a file for use with external citation management software.

Comments (0)