Pexion A New Treatment for Canine Idiopathic Epilepsy - PetSci






Getgetnet.bizMedicine for epilepsy in dogs


2/10/2014
03:25 | Author: Molly Young

Medicine for epilepsy in dogs
Pexion A New Treatment for Canine Idiopathic Epilepsy - PetSci

he had many fits all through the day and night which was Tuesday the 2nd of sept he still is not 100% now we are waiting to hear from our vet as they do not really know what to do with him he is only 17mouths x. Hi daisy my border collie brody has been on pexion and phenobarbital for two months and totally agree with you that it does not seen to stop the fits.

The benefit/risk assessment for the individual dog should take into account the details in the product literature.

Thank you so much Faye – Bronte is off Pexion now x.

Hi Wendy – yes, our own dog had the exact pattern that you describe. He was staggering, crashing into things, falling over, etc but he did recover and was back to being bouncy, happy and enjoying life after three days. It is an ongoing process for us at the moment as all blood tests for thyroid problems etc are proving inconclusive and we are changing the medication. He was diagnosed with epilepsy in February and was seizure free for three months on Pexion. We rushed him to the vet and it took three days for him to settle again. Fingers crossed here for you and dog. He had another small fit, but then had eight siezures close together a few weeks ago and was exactly as you describe.

Sorry Wendy I didn’t see the question you asked about protein. Kay. I will NOT put Ernie on phenobarbital – he came off all drugs 9 days ago and no fits yet…. I will look at the link that Val b posted. I haven’t heard of a link to protein. Ernie has a good dry dog food with no grains at all, but I would consider the raw if he has fits and they are not controlled by other drugs. if I have to I might start on potassium bromide. I am sorry to hear about your dog Diane, I think it is trial and error with all drugs, drugs all have pros and cons. Also if your dog is just one isn’t that unusual for it to be idiopathic epilepsy? I thought the fits normally start around the age of 2 for that? Has the vet talked about any other causes? Suggested an MRI scan? I think the raw diet my work for some. his last fit was 12th July so he was due to have a fit a fortnight after that, so far so good. Has your vet mentioned potassium bromide? I think that you can use that with phenobarbital if your dog tolerates it.

Spent more time in hospital as the fits were not controlled, now also has pexion 100mg twise a day. Took him in overnight as it was a Sunday they took good care of him and put him on phenobarbital. Started him on a small dose but now has 60mg twise a day has cluster fits every three weeks. He went three weeks without any fits and then to the pattern had another cluster fits that lasted all day don’t know where to go from here. Hi my border collie started fitting just after his first birthday which was a total shock for us as a family.

Tagged with: canine dog epilepsy imepitoin pexion phenobarbital potassium bromide seizure.

Owners should consult their vet and explore all the possibilities when dealing with an epileptic dog.

But she is also on the other meds. Shani is just over 4kgs and has just had her pheno reduced to 15mg. Luckily your dog is on a very small dose of epiphen.I imagine he is a standard if he is 6.25kg.

Has anyone else experienced this with their dog?. Well my Daisy managed to go 4 weeks and 1 day without a fit until Monday of this week where she had 8 fits in 24 hours. I rushed her to the vets because she was in a very bad way (hallucinating, stressed and not with it) now 3 days on she is still a bit nervous, has only just remembered who we are but the dog I know seems to be gone. I am hoping that it is a result of so many fits in such a short period of time and she will get back to normal. I am hoping and praying that that is not the case and she is the way she is now because of so many fits in such a short period of time. My vet has now agreed with me after 2 months of ling them that Pexion is not working! She is booked in for an MRI next week because my vet suspects that she has a brain tumour.

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Transition to other types of antiepileptic therapy should be done gradually and with appropriate clinical supervision. The efficacy of the veterinary medicinal product in dogs with status epilepticus and cluster seizures has not been investigated. Therefore, imepitoin should not be used as primary treatment in dogs with cluster seizures and status epilepticus.

We recently wrote about canine idiopathic epilepsy, a form of epilepsy where the cause remains unknown. Today we are looking at a new treatment; Pexion.

Recently Boehringer Ingelheim has announced their latest product for the treatment of canine epilepsy, Pexion (Pexion) an alternative to the traditional phenobarbital or potassium bromide treatments given to epileptic dogs.

The severity of epilepsy can vary greatly between individual sufferers. Some dogs may experience a single, isolated seizure, whilst other can experience multiple seizures every week.

Protein should not be restricted in the diet unless the dog has symptoms of hepatic encephalopathy.

Posted by: James Watts May 4, 2013 in Health Care 421 Comments.

The introduction of Pexion gives owners and vets a greater choice when it comes to treatment, but does not replace phenobarbital and potassium bromide.

Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in dogs with severely impaired hepatic function, severe renal or severe cardiovascular disorders.

A study conducted on Pexion during its development compared it to the traditional anti-epileptic medicine phenobarbital. 1 Is Pexion a Better Alternative? The Pexion study showed that it had an effectiveness equivalent to phenobarbital, however, Pexion may be considered a better alternative as it has less severe side effects. A 20 week study of 226 dogs taking the medications found Pexion matched phenobarbital in efficacy, reducing the occurence of seizures by around 50%.

He has been seen by the vrcc veterinary referrals cancer and critical care centre they have ruled out brain tumours or anything else other than what they have said he has. Hi Kay I’ve investigated that border collies if they have idiopathic epilepsy starts after there first birthday which is what happened to brody. Thank you for your advice.

One way of giving taurine is in the supplement Epitaur whcih also contains other nutrients vital for an epileptic dog. http://www.viovet.co.uk/Vetri-Science_Epitaur_Capsules/c423/.

What Is Pexion? Unlike other treatments for canine epilepsy, Pexion contains the active ingredient Imepitoin. Imepitoin acts in a similar manner to previous anti-epileptic medicines, potassium bromide and phenobarbital, in that it works to suppress electrical activity in the brain. If you’re dog has been prescribed Pexion, let us know how your dog is getting on in the comments below. Join the discussion on how other dog owners are getting on with Pexion and keep the community updated with your progress.

In dogs where seizures occur more freqently, such as once a month or more, treatment should be considered.

Pexion 100 mg and 400 mg tablets for dogs Contra-indications, warnings, etc.

Is this an alternative to milk thistle? Hello Susan. The seizures occur less frequently now than when he was on Pexion, about three weeks apart. Hi Jean thank you for your reply. My dachsie is around 6.25 kg smooth. I will definiy look into giving the Epitaur. I asked the vet about milk thistle but he didn’t feel it was necessary at this stage (?) Otherwise he is fine with good energy levels. His takes 12.5mg pheno twice a day.

This means the regular testing required to ensure that a dog’s liver remains healthy is not needed whilst being given Pexion. Unlike phenobarbital, Pexion does not pose a hepatotoxicity risk (liver toxicity).

Imepitoin partially activates GABA receptors, which are responsible for reducing electrical activity between nerve cells. Specifically, Imepitoin also has a weak blocking effect on calcium channels that allow electrical signals to be propagated along nerve cells. This partial activation of the GABA receptors is believed to reduce electrical activity and help prevent seizures.

In dogs where seizures occur infrequently owners may consider not using any medication at all, avoiding the side effects associated with anti-epileptic medications. It is commonly cited that around 0.5 to 5% of dogs suffer from some form of epilepsy, the severity varying between breeds and individuals.

So I have to say that this medication has not worked for my dog. My dachshund started having seizures shortly before his second birthday about three weeks apart. After all the tests came back normal the vet put him on Pexion. He is now on Epiphen and so far he has not had any more fits. Unfortunay the seizures increased in frequency despite going to the maximum dose. Worried about side effects though.

Every three to four weeks he has cluster fits x.

My old vet back in England knew nothing about milk thistle, many vets aren’t familiar with things unless they are drugs, which milk thistle isn’t. The point of milk thistle is to try to prevent damage to the liver and not wait until there are problems. This link ls you what’s in the capsules and what effect they have http://www.petmeds.co.uk/Dogs/Dog-Health/Supplements/Herbal/Epitaur-Capsules/p/I0020457 Shani always had milk thistle separay until her liver enzymes were raised and now she has Doxion, which contains SAMe and milk thistle as well as other nutrients to aid the liver. Epitaur is a support for the liver, but does not contain milk thistle.

No loss of anticonvulsant efficacy (tolerance development) during continuous treatment of 4 weeks was observed in experimental studies lasting 4 weeks.

Disclaimer: This article was written as a response to the release of Pexion and as a follow up to a previous article concerning idiopathic epilepsy. Image Credit: Onkel_wart References:. I am not affiliated with the product (Pexion) or the manufacturer (Boehringer).

There is so much on the net now about BARF feeding for pets. I have said so often on this blog that fits were never mentioned in dogs fifty years ago and indeed I had never heard of dogs having fits until my own beautiful border collie started having them a year ago. Please do try cutting out all processed dog food, that includes tins of food. All the best, Elizabeth. I am convinced it is todays dry processed dog food that predisposes to the increase of fits in our beloved animals. Its very easy and much cheaper than those bags of nuts that are all sprayed with some ghastly fat spray to make them more edible. I am now giving my dogs who are young, raw mashed vegetables twice a day(that includes ALL VEGETABLES AND MOST FRUIT ) raw bones every other day for their teeth and raw heart, liver, chicken legs and wings and any other raw steak I can get cheaply from the butcher. Now I have lost her and I do not want to lose my young collie who is just one. What a worry for you Diane that your collie is having fits as he is so young. Please just give it a try anyway.

Cluster seizures – When multiple seizures occur in one 24 hour period Status epilepticus – A persistent epileptic state that lasts for longer than 5 minutes.

That’s useful information, thanks a lot Kay and I hope all goes well with your dog xx.

Hi Wendy If your dog has not had other medication for fits/epilepsy, it might be worth changing the drug… Talk to your vet and see what he/she says, also show them this website. My vet read from the veterinary drug handbook about Pexion and said in some cases the fits will INCREASE on Pexion, which is why he took my dog off of the drug. I was not happy about the dose my dog was having as there was no change at all in the frequency of fits and as it happened he had a couple 12 hours apart, which may have been due to Pexion.

Val B Pexion is the one epilepsy drug you can just stop without the need to wean off.

For more information about epilepsy, such as the causes, what to do during a seizure and more, see this article.

Please can you give me any advice?. My bichon is 5 years old and recently started to have fits. He is now on Pexion 2 in the morning followed by 2 at night. They are defintly not working. Then he may go 5 days without a fit. I feel that I can’t leave him alone in case he hurts himself. Sometimes he is having four fits in two days.

I can only advise talking to your vet about your experiences. Hi Niki I am sorry to hear about your dog. I hope things get better for you soon Kay. You know your dog best, how he is acting on the tablets and whether he is worse or if there is no change. If you think that your dog has become worse or is fitting more then perhaps ask if you could try another drug.

Fingers crossed. Hi Val He decreased gradually, five days with one morning and night and five days with a half morning and night… He has not replaced it with anything though, no fits as of yet…. a fortnight. he used to have one fit approx. So since last Thursday no tablets of anything.

Daisy is still not 100% after nearly a week, she seems to have forgotten certain words and is not interested in the slightest about going for a walk whereas before the 8 fits she loved her walks. Hi Sal, have you changed your dogs medication yet? I have had a long discussion today about changing Daisy’s medication. I have to start her tomorrow on epiphen and she is also going to give me kappra to keep in the house to give to her if she has cluster fits again. She is going on Thursday to vets just so that she can check her over, fingers crossed her problems at the minute are due to so many fits in such a short time, please let me know how you get on with the medication Sal, all the best of luck.

I forgot to post this. http://www.noahcompendium.co.uk/Boehringer_Ingelheim_Limited/Pexion_100_mg_and_400_mg_tablets_for_dogs/-61207.html.

Thank you for the advice Kay, Daisy has been on 1200mg of Pexion for 13 days now, so far she has not had a fit but she has never gone more than 2 weeks without one, so I am expecting one very soon. Iam not gong to increase her dose any higher if she has another fit even though the vet will probably recommend it. He said that it is something about the protein in their diet, do you anything about his Kay?. I am going to insist that she tries another medication even though the vet says that other medications makes them drowsy and they have no quality of life! I was talking o someone yesterday who’s dog as epilepsy but the epilepsy is controlled by diet.

Link to Epilepsy Support is http://www.canineepilepsysupport.co.uk and my contact is Anne Morley at Good luck xx. When Bronte first began having fits I got in touch with the Canine Epilepsy Support Group who advised me to change her food to the lowest protein food available and rotate it (Chappie, Butcher’s etc.) I also used Bach’s Rescue Remedy and gave her a supplement called Taurine. I am not convinced and thinking of taking her off it. Hi Wendy, I do wish you luck finding the right medication. I noticed that someone had mentioned protein in the diet. Bronte has never had any meds other than Pexion and I agreed to it because I was told it was a wonder drug with no side effects.

people may have seen it but I was interested in this on that link…

Did your vet reduce the dose gradually, Kay, or just stop it? Some say it is safe to stop at any time and others recommend it is done gradually.

There is a great epilepsy group that you could join online http://www.canine-epilepsy.com/ It’s mostly American but there are quite a lot of other nationalities too and the best one I’ve ever discovered. If your boy is still having seizure with not a lot of time between you might need to increase the pheno slightly. And I’ve had epi dogs since the 80s.

See here for more information about Pexion.

I took her down to Cambridge University to their Animal Hospital as Anne Van Haesenbrauk a top neurologist had studied canine epilepsy and I was so desperate to help my beautiful dog. Nothing worked and when she was just on the pexion we thought we’d cracked it as she went for 6 weeks nearly without a fit, and then she started having them weekly-every saturday and she had in excess of 30 seizures over the weekend, she spent the last 2 weekends at my vets heavily sedated with valium. If you look up the canine epilepsy guardian angels website, they have loads of information on there, most of the people have had an epileptic animal and are full of ideas that you may find helpful. Dear Dianne, My dog Izzy was put on pexion when it had been out a few months, she had her first fit at a year old and continued to have 3 or 4 fits every 3 weeks. We continued on the medication adjusting the doses but she still had regular fits until she had a really bad episode and we found that the bromide was not suitable and we nearly lost her t pancreatitus. My postings on this forum are exactly a year ago, from May/June to 2nd September hen Izzy was pts and no longer suffering. My vet put her on epiphen initially and when that didn’t stop the siezures added Lebromide, she still continued to have seizures regular as clockwork. Love Amanda x. May the angels be with you. After the first weekend I stopped the Pexion as suggested in the notes and wish I had put “The Valium Protocol” in place before stopping the Pexion. My vets could only sedate her to stop the fits temporarily and as soon as they brought her round the clusters continued- after so many (every 3/4 minutes) her temperature had risen to high and we don’t think she’d have been able to function like that, so the decision was made by us and my vet to put her down- she was only 3 and a half. I wish you all the luck in the world and hope you find something that works so you don’t have to go through the pain of losing your dog. They did a brain scan and drew fluid from the spinal column and found nothing so she was diagnosed with Idiopathic Epilepsy. I had also changed her diet to BARF using mainly chicken inc bones and found other natural ways like Bachs rescue oil, skullcap & valerian tablets. It was at this time that pexion came out and I weaned Izzy off the Epiphen whilst starting with pexion. I believe to this day that if I had reduced the dose slowly it may have made things better for her as the withdrawal brought on the clusters that took her life.

I also have a dog with liver disease (her uncle) so know how to help Shani deal with any problems caused by her drugs. You could put her on Epitaur, which is for epieltpci dogs and recommended by Richard Allport, the homeopathic vet. My Shani is just over 9lbs, a mini longhaired. she is now on 15mgs pheno BID but also Gabapentin and potassium bromide. But she is not my first epi and I chose pheno because of its proven success. Susan, You don’t say what dose of Epiphen your Dachsie is on, nor whether your Dachsie is mini or standard. Side effect initially is the ataxia, which should disapear in two or three weeks. Here is a link to it: http://www.viovet.co.uk/Vetri-Science_Epitaur_Capsules/c423/. She should have pheno level tested at 2 weeks and periodically thereafter. She can be given milk thistle to help the liver deal with any drugs. She was 7 years old in May and has been epileptic since birth.

The pharmacological response to imepitoin may vary and efficacy may not be complete. In non-responders, an increase in seizure frequency may be observed. On treatment, some dogs will be free of seizures, in other dogs a reduction of the number of seizures will be observed, whilst others may be non-responders. Nevertheless imepitoin is considered to be a suitable treatment option in some dogs because of its safety profile. Should seizures not be adequay controlled, further diagnostic measures and other antiepileptic treatment should be considered.


Medicine for epilepsy in dogs