Metformin mechanism of action








Glucophage, Glucophage XR (Metformin Hcl) Drug Information

11/13/2014
03:04 | Author: Chloe Allen

Metformin mechanism of action
Glucophage, Glucophage XR (Metformin Hcl) Drug Information

Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production.

A 16-week, double-blind, placebo-controlled, dose-response study of GLUCOPHAGE XR, taken once daily with the evening meal or twice daily with meals, was conducted in patients with type 2 diabetes who had failed to achieve glycemic control with diet and exercise (HbA 1c 7.0%-11.0%, FPG 126-280 mg/dL). Changes in glycemic control and body weight are shown in Table 6.

GLUCOPHAGE (metformin hydrochloride) Tablets and GLUCOPHAGE XR (metformin hydrochloride) Extended-Release Tablets treatment should not be initiated in patients ≥ 80 years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced (see WARNINGS and DOSAGE AND ADMINISTRATION ).

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Molecular mechanism of action of metformin old or new insights?

9/12/2014
01:52 | Author: Chloe Allen

Metformin mechanism of action
Molecular mechanism of action of metformin old or new insights?

Metformin was discovered before the era of target-based drug discovery and its molecular mechanism of action remains an area of vigorous.

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In addition, there are likely to be other beneficial effects, including a reduction in cardiovascular disease and mortality compared with non-intensive treatment and a possible reduction in cancer incidence, which has been seen in some, but not all, studies. As metformin was discovered in the era before modern target-based drug discovery, the molecular details of its mechanism of action were not established before it was used clinically and these continue to be an area of vigorous research.

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Metforminmdashmode of action and clinical implications for

7/11/2014
01:28 | Author: Jeremy Rodriguez

Mechanism of action in pharmacology
Metforminmdashmode of action and clinical implications for

The centre of metformin's mechanism of action is the alteration of the energy metabolism of the cell. Metformin exerts its prevailing.

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DrugBank Metformin (DB00331)

5/10/2014
03:24 | Author: Allison King

Metformin mechanism of action
DrugBank Metformin (DB00331)

Metformin may induce weight loss and is the drug of choice for. Mechanism of action, Metformin's mechanisms of action differ from other.

mL/minute following single oral dose of 0.5-1.5 g. Metformin is removed by hemodialysis at a rate of approximay 170 ml/min under good hemodynamic conditions.

The volume of distribution following IV administration is 63-276 L, likely due to less binding in the GI tract and/or different methods used to determine volume of distribution. 654 L for metformin 850 mg administered as a single dose.

Metformin is not metabolized.

In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate.

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Metformin in the treatment of adults with type 2 diabetes mellitus

3/9/2014
05:40 | Author: Jeremy Rodriguez

Metformin mechanism of action
Metformin in the treatment of adults with type 2 diabetes mellitus

The molecular mechanisms of metformin action are not fully known. Activation of the enzyme AMP-activated protein kinase (AMPK) appears to.

As a result of the improvement in glycemic control, serum insulin concentrations decline slightly. In addition, metformin increases insulin-mediated glucose utilization in peripheral tissues (such as muscle and liver), particularly after meals, and has an antilipolytic effect that lowers serum free fatty acid concentrations, thereby reducing substrate availability for gluconeogenesis. Metformin is effective only in the presence of insulin, and its major effect is to decrease hepatic glucose output.

AMPK-dependent inhibitory phosphorylation of acetyl-coA carboxylases Acc1 and Acc2 then suppresses lipogenesis and lowers cellular fatty acid synthesis in liver and muscle, which in turn improves insulin sensitivity and reduces blood glucose levels.

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