Rivotril 0.5mg Tab Price,Side-Effects,Generic-Alternatives Dosage
Brand Name, Company Name, MRP (Rs.) Ozepam 0.5mg Tab, Innova Life Sciences, 19.20. Lonazep 0.5mg Tab, Sun Pharma, 27.15. Lonazep MD 0.5mg Tab.
Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow angle glaucoma.
Carbamazepine, phenobarbitone or phenytoin may accelerate clonazepam metabolism. Potentially Fatal: Increased sedative effect with alcohol, general anaesthetics and TCAs.
Rarely, blood dyscrasias. May produce diminished reflexes or coma. Drowsiness, fatigue, muscular hypotonia, coordination disturbances, dizziness, vertigo, anorexia, visual disturbances, libido changes. Potentially Fatal: Salivary or bronchial hypersecretion leading to respiratory problems (children).
It raises the threshold for propagation of seizure activity and prevents generalisation of focal or local activity. Excretion: Urine (as free or conjugated metabolites); 20-40 hr (elimination half-life). Clonazepam is an effective anticonvulsant. Metabolism: Extensively hepatic; converted to 7-aminoclonazepam. Clinically, it improves focal epilepsy and generalised seizures. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 4 hr. Protein-binding: 86%. It is also believed to enhance the activity of GABA, and acts as anxiolytic. Distribution: Crosses the placenta; enters breast milk.
Neonates, chronic pulmonary insufficiency, hepatic/renal dysfunction, porphyria, elderly; pregnancy and lactation.