Clonazepam - The Palliative Care Handbook
Increased clinical effect/toxicity of clonazepam (due to increased blood Cost: Approx $0.06 to $0.11 per tab, $0.74 per mL oral drops, $3.80 per 1 mg inj. Notes.
The Palliative Care Handbook Context (Rivotril™, Paxam™).
Mechanism of action: may enhance the effect of GABA, an inhibitory neurotransmitter in the CNS.
Send Feedback Topic Code: 19411. Once printed, this is no longer a controlled document. Note: Only the electronic version is controlled.
diazepam 5 mg = lorazepam 0.5 to 1 mg = clonazepam 0.5 mg = temazepam 10 mg = midazolam 7.5 mg = triazolam 0.25 mg.
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Contraindications/cautions: avoid sudden withdrawal, respiratory depression Adverse reactions:
Pharmacological properties of benzodiazepines and other hypnotics Drug Anxiolytic Night sedation Muscle relaxant Anticonvulsant Diazepam +++ + +++ ++ Lorazepam +++ ++ + + Clonazepam ++ + + +++ Temazepam + +++ + + Midazolam + +++ + +++ Zopiclone - +++
(see Who's Who ) Issue Date: July 2010 Next Review: July 2011 Keywords:
Syringe driver: see syringe driver compatibility table.
Half life: > 30 hours (18 to 45 hours) Availability :
Class: anticonvulsant - benzodiazepine Indication: epilepsy, convulsions.
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Onset: oral (seizure control) 20 to 40 minutes.
Cost: Approx $0.06 to $0.11 per tab, $0.74 per mL oral drops, $3.80 per 1 mg inj Notes:
Metabolism/clearance: metabolised by metabolising enzyme CYP3A4/5/7 mainly in the liver Interactions:
Unlicensed indications: sedation, anxiety, agitation, restless leg syndrome, neuropathic pain, dyspnoea, hiccups, myoclonic jerks, subcutaneous injection /infusion.
Dosing: sedation, anxiety, agitation, restless leg syndrome, neuropathic pain, dyspnoea, hiccups, convulsions.