Cognitive side effects of antiepileptic drugs
Cognitive side effects of antiepileptic drugs. Ortinski P, Meador KJ. Antiepileptic drugs produce global changes in the excitation levels in the central nervous.
Polypharmacy and high blood levels of an antiepileptic drug (AED) increase the risk of cognitive side effects. Different effects have been demonstrated for some AEDs, but comparative data are incomplete across all of them. Antiepileptic drugs produce global changes in the excitation levels in the central nervous system and often lead to cognitive and behavioral deficits. AEDs can have positive or negative effects on mood, providing another consideration in choosing the course of treatment. A number of consistent risk factors have been established. These deficits vary and must be considered independently in every patient. Other factors such as patient age and type/frequency of seizures may also be important contributors to the patient's cognitive state.
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